Histone Methyltransferases
نویسندگان
چکیده
منابع مشابه
Arabidopsis Histone Lysine Methyltransferases.
In eukaryotes, changes in chromatin structure regulate the access of gene regulatory sequences to the transcriptional machinery and play important roles in the repression of transposable elements, thereby protecting genome integrity. Chromatin dynamics and gene expression states are highly correlated, with DNA methylation and histone post-translational modifications playing important roles in t...
متن کاملAssay development for histone methyltransferases.
Epigenetic modifications play a crucial role in human diseases. Unlike genetic mutations, however, they do not change the underlying DNA sequences. Epigenetic phenomena have gained increased attention in the field of cancer research, with many studies indicating that they are significantly involved in tumor establishment and progression. Histone methyltransferases (HMTs) are a large group of en...
متن کاملChemical Probes of Histone Lysine Methyltransferases
Growing evidence suggests that histone methyltransferases (HMTs, also known as protein methyltransferases (PMTs)) play an important role in diverse biological processes and human diseases by regulating gene expression and the chromatin state. Therefore, HMTs have been increasingly recognized by the biomedical community as a class of potential therapeutic targets. High quality chemical probes of...
متن کاملDietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases
Methylation of DNA and histone proteins are mutually involved in the epigenetic regulation of gene expression mediated by DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs). DNMTs methylate cytosine residues within gene promoters, whereas HMTs catalyze the transfer of methyl groups to lysine and arginine residues of histone proteins, thus causing chromatin condensation and tra...
متن کاملCorrection: Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases
[This corrects the article DOI: 10.1371/journal.pone.0162956.].
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Methods in molecular biology
سال: 2022
ISSN: ['1940-6029', '1064-3745']
DOI: https://doi.org/10.1007/978-1-0716-2481-4